Just a couple blocks from the Ohio River sit the remaining buildings of Greiner’s Brewery.
In 1854 Mathew Greiner moved his brewery from Cincinnati to Madison Indiana. Two years later he built this three story building (four stories if you count the hipped-roof tower). Prohibition sent the brewery into bankruptcy and was dissolved in 1918. For the next 6 decades the building housed a grocery, a farm and dairy supply store, and Madison Machine Products and finally Mayflower Transfer and Storage.  It has been converted into an artist’s studio and gallery.
The historic “Greiner’s Brewery, Cash For Barley” sign that graced the front of the building during the 1870s has been repainted on the side facing Park Avenue.
The Greiner Brewery building is listed in the National Register of Historic Places and is designated as a National Landmark.